磷脂酶A2 | 食品添加物合法業者資訊網

磷脂酶A2（PLA2）代表的是一类可水解甘油磷脂的sn-2酯以产生脂肪酸和溶血磷脂的酶。...近期的基因破坏研究表明，该酶可在花生四烯酸释放于受刺激的巨噬细胞中发挥作用。...PhospholipaseA2regulationofarachidonicacidmobilization.

Phospholipase A2 (PLA2) designates a class of enzymes that hydrolyze the sn-2 ester of glycerophospholipids to produce a fatty acid and a lysophospholipid. It has become clear that some of these enzymes liberate arachidonic acid in mammalian cells for the biosynthesis of eicosanoids, and thus there has been considerable interest in developing PLA2 inhibitors. Based on amino acid sequences, there are now more than 12 distinct groups of mammalian PLA2s, as well as many non-mammalian forms, all of which have been classified into 14 distinct groups with many subgroups.

Since naturally occurring phospholipids have virtually no solubility in water, PLA2 must bind to the lipid-water interface to access its substrate, and it is clear that catalysis occurs at the interface (interfacial catalysis). One has to be careful with the interpretation of kinetic data including inhibition data, and in fact many of the...