Macrolides for treatment of chronic obstructive pulmonary di... | 食品添加物合法業者資訊網

由XJSun著作·2019·被引用4次—Theideaoflong-termmacrolidetherapyforCOPDwasderivedfromthesuccessfultreatmentinreducingexacerbationandimprovinglungfunction ...

Chronic obstructive pulmonary disease (COPD) is a common disease characterized by continued airflow limitation that is caused by inflammation and autoimmune response. Acute exacerbation of COPD (AECOPD) will increase risk of death, result in a more rapid decline of lung function, and reduce quality of life. COPD inflammation is not only limited to the lungs, but also involves multiple organs, leading to coronary heart disease, depression, skeletal muscle atrophy, and other systemic complications. Clinical study showed that long-term macrolide could reduce the frequency of AECOPD.[1] However, there are still some controversies and concerns on side effects such as drug resistance, cardiac toxicity, and hearing impairment caused by long-term macrolide therapy for COPD.

The idea of long-term macrolide therapy for COPD was derived ...