Macrolide Therapy Could Reduce Acute Exacerbations in ... | 食品添加物合法業者資訊網

2019年6月21日—MacrolideTherapyCouldReduceAcuteExacerbationsinPatientsWithCOPD...Accordingtoameta-analysis,long-termmacrolidetherapyatlow ...

Long-term macrolide therapy at low doses may reduce the number of acute exacerbations for patients with chronic obstructive pulmonary disease (COPD), according to a review article in Dovepress.

“It is known to us that over 50% of acute exacerbations are caused by bacterial infections, accompanied by increased airway inflammation. As macrolides have anti-inflammatory, anti-viral, and immunomodulatory effects, scholars have carried out clinical trials to use it to prevent exacerbations of COPD,” researchers said. “However, this method is not generally accepted. We, therefore, try to explore the efficacy of macrolides in preventing the acute exacerbation of COPD by statistical methods.”

Researchers performed a systematic literature search in PubMed, Embase, and the Cochrane Library database. Randomized controlled trials (RCT) that reported long-term use o...