PHOSPHOLIPASE C | 食品添加物合法業者資訊網

由CABill著作·2020·被引用10次—Phosphoinositide-specific-phospholipaseCβ(PLCβ)isthemaineffectorofGαqstimulationthatiscoupledtoreceptorsbindingacetylcholine, ...

PLC is a cytoplasmic protein that controls the levels of PIP2 in cells by localizing within or outside of lipid rafts in the plasma membrane and catalyzing the hydrolysis of phosphorylated forms of phosphatidyl inositol in response to cellular stimuli ( and ). These enzymes have been reported to increase the rate of lysis of phosphatidyl inositol >1000s−1 at 30°C at low concentrations of substrate, but is likely to reach rates of >5000s−1 (as reviewed by [16]). Therefore, targeting of PLC to the plasma membrane plays a critical role in the functioning of this enzyme. The preferred substrate of PLC is PIP2, a relatively uncommon phospholipid in the plasma membrane, followed by phosphatidyl inositol phosphate (PIP), and then phosphatidyl inositol (PI). Cleavage of PIP2 leads to the generation of two products. One product, diacylglycerol (DAG), ac...