Pyruvate Dehydrogenase (PDH) | 食品添加物合法業者資訊網

​​​PyruvateDehydrogenasecomplex(PDH)connectsthecitricacidcycleandsubsquentoxidativephosphorylationtotheglycolysis,gluconeogenesisandlipidand ...

​​​​​​Structure, regulation and analysis of this key regulatory site in cellular metabolism.

​​​Pyruvate Dehydrogenase complex (PDH) connects the citric acid cycle and subsquent oxidative phosphorylation to the glycolysis, gluconeogenesis and lipid and amino acid metabolism pathways.

PDH catalyzes the oxidative decarboxylation of pyruvate to produce acetyl coenzyme A (acetyl-CoA), NADH and CO2. PDH facilitates the use of carbohydrate to meet energy demands: when carbohydrate stores are depleted in mammals, PDH activity is downregulated to limit the use of glucose by oxidative phosphorylation. Fatty acids or ketone bodies are then used as an energy source in tissues such as heart and skeletal muscle.​​​

PDH is a 9.5 MDa complex consisting of multiple copies of three enzymes: pyruvate dehydrogenase (E1), dihydrolipoamide transacetylase (E2) and dihyd...