Distinct Structural Mechanisms for Inhibition of Pyruvate ... | 食品添加物合法業者資訊網

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Dichloroacetate (DCA) is a metabolic modulator that inhibits mitochondrial pyruvate dehydrogenase kinase and increases mitochondrial oxidative phosphorylation. Read More

由 M Kato 著作 · 2007 · 被引用 194 次 — Pyruvate dehydrogenase kinase (PDK) isoforms are molecular switches that downregulate ... Finally, the antitumor compound radicicol (Figure 1) inhibits the ... Read More

由 G Sutendra 著作 · 2013 · 被引用 236 次 — Inhibition of PDK with either small interfering RNAs or the orphan drug dichloroacetate (DCA) shifts the metabolism of cancer cells from ... Read More

由 WR Mann 著作 · 2000 · 被引用 36 次 — Diverse mechanisms of inhibition of pyruvate dehydrogenase kinase by structurally ... Some compounds directly inhibited the catalytic activity of PDKs. Read More

由 JA Morrell 著作 · 2003 · 被引用 66 次 — In order to explore the isoenzyme selectivity of these compounds kinase assays for PDHK1, PDHK2 and. PDHK4 were established. The IC50 values for inhibition of ... Read More

由 X Zhou 著作 · 2016 · 被引用 31 次 — Pyruvate dehydrogenase kinases (PDKs) are key enzymes in glucose metabolism, negatively regulating pyruvate dehyrogenase complex (PDC) activity through ... Read More