Triflate | 食品添加物合法業者資訊網

Triflate,alsoknownbythesystematicnametrifluoromethanesulfonate,isafunctionalgroupwiththeformulaCF3SO3−.Thetriflategroupisoftenrepresented ...

Triflate, also known by the systematic name trifluoromethanesulfonate, is a functional group with the formula CF3SO3−. The triflate group is often represented by −OTf, as opposed to −Tf (triflyl). For example, n-butyl triflate can be written as CH3CH2CH2CH2OTf.

The corresponding triflate anion, CF 3SO− 3, is an extremely stable polyatomic ion; this comes from the fact that triflic acid (CF3SO3H) is a superacid; i.e. it is more acidic than pure sulfuric acid, already one of the strongest acids known.

A triflate group is an excellent leaving group used in certain organic reactions such as nucleophilic substitution, Suzuki couplings and Heck reactions. Since alkyl triflates are extremely reactive in SN2 reactions, they must be...