Microcrystalline Cellulose as Pharmaceutical Excipient | 食品添加物合法業者資訊網

由AYChaerunisaa著作·2019·被引用35次—Microcrystallinecelluloseisapurepartiallydepolymerizedcellulosesynthesizedfromα-celluloseprecursorwithhydrolysisbymineralacids,usuallyinforms ...

Cellulose, a fibrous carbohydrate found in all plants, is the most abundant natural polymer with biomass production of 50 billion tons per year [1]. Cellulose is a linear polymer of glucose. Based on solubility in alkaline, cellulose is divided into three groups which are alpha, beta, and gamma celluloses. Microcrystalline cellulose (MCC) is a purified, partially depolymerized cellulose having the formula (C6H10O5)n. It is prepared by treating alpha cellulose with mineral acids (type Ib). This polysaccharide polymer consists of a linear chain of several hundred to over ten thousand β(1 → 4) linked D-glucose units, consisting of linear chains of β-1,4-d anhydroglucopyranosyl units. Raw material used for MMC preparation is a pulp from a fibrous plant such as conifer wood. Cotton is also a possible cellulose source for MCC [2, 3]. Pharmaceutical grade MCC, which needs a high-quality pulp, used wood as the most common source. From such wooden source, cellulose cha...